1. Sulforaphane-mediated upregulation of the nrf2 pathway could reduce oxidative DNA damage and inflammation induced by UV radiation.

2. Ultraviolet (UV) from sunlight is carcinogenic that can burn skin, enhance inflammation, and drive skin carcinogenesis. It has shown that sulforaphane inhibits chemically induced skin carcinogenesis.

3. Sulforaphane protects against UVA radiation, associated with tanning and skin ageing, without affecting the DNA level.

Ref: 1 , 2

1. Sulforaphane involves in the induction of autophagy.

2. Autophagy helps rid ageing cells and decrease inflammation in the body.

3. Autophagy also helps remove toxic proteins from the cells attributed to neurodegenerative diseases.

Ref: 3,4,5

1. Studies have shown that sulforaphane reduces the effects of various types of inflammation on overall health, energy levels, and cognitive memory function.

2. Chronic inflammation is associated with normal and pathological ageing.

3. Inflammation is also the prime candidate among potential mortality, capability, and cognition determinants up to extreme old age.

Ref: 6,7,8,9,10

1. Outdoor air pollution and particulate matter from air pollution are classified as carcinogenic to humans.

2. The predominant exposure to benzene, a known human carcinogen, arises from on-road mobile source emission and smoking, an important source of exposure to benzene.

3. Clinical trial shows rapid and highly durable elevation of the detoxification of benzene through consumption of broccoli beverage, which is rich in glucoraphanin and sulforaphane.

Ref: 11,12,13,14,15

1. Sulforaphane is a promising strategy to combat obesity and obesity-related metabolic disorder.

2. Studies indicate that glucoraphanin, the precursor of sulforaphane, may effectively prevent obesity and related metabolic disorders.

3. Supplementation with a dietary dose of glucoraphanin, the precursor of sulforaphane, helps decrease plasma liver enzymes for the liver to carry out its functions.

Ref: 16,17,18

1. Diet rich in high glucoraphanin broccoli, a source of sulforaphane, reduces plasma LDL cholesterol and increases HDL cholesterol significantly.

Ref: 19,20,21

1. Sulforaphane as a new potential anti-diabetic compound improves glucose tolerance and reduces excessive glucose production.

2. Sulforaphane reduces hepatic glucose production and improves glucose control in lifestyle-related type 2 diabetes patients.

Ref: 22,23

1. Cardiovascular disease is a class of diseases that involve the heart or blood vessels, such as ischemic heart disease, hypertensive heart disease, and peripheral artery disease.

2. Cardiovascular diseases rank high among the most common disorders in adults and are the number one cause of death globally.

3. Regular consumption of cruciferous vegetables, a rich source of sulforaphane, may provide a preventative dietary approach to reducing cardiovascular disease risk and mortality.

Ref: 24,25,26,27

1. Studies have shown that oral administration of sulforaphane increased blood glutathione, a major antioxidant, levels in humans.

2. Sulforaphane is an indirect antioxidant and upregulates multiple antioxidant pathways without being consumed in the antioxidation process. It boosts the antioxidant capacity of cells by at least two major indirect mechanisms: induction of phase 2 cytoprotective enzymes and dramatically increasing cellular glutathione levels.

Ref: 28,29

1. Intake of Sulforaphane, exceptionally high in broccoli and broccoli sprouts, may lower overall cancer risk, including colon and prostate cancer.

2. Lung cancer is the second most common cancer and represents the leading cause of cancer death in both men and women. Cruciferous vegetables, a major source of sulforaphane, intake is inversely associated with lung cancer risk among smokers.

Ref: 30,31,32,33,34,35,36

1. Sulforaphane from broccoli reduces symptoms of Autism through a series of randomised, double-blind studies.

2. Dietary sulforaphane, of recognized low toxicity, was selected for its capacity to reverse abnormalities that have been associated with Autism spectrum disorder (ASD).

3. Autism spectrum disorder (ASD) affects 1 in 68 children. There are no validated pharmacologic treatments for the core symptoms of ASD. Clinical trials have shown that sulforaphane from broccoli sprouts could significantly reduce the behavioral symptoms of ASD.

Ref: 37,38,39

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